To begin with, an anti-Christ is an adversary. And the ultimate adversary is Satan.
1 Peter 5:8 – Be sober, be vigilant; because your adversary the devil, as a roaring lion, walketh about, seeking whom he may devour:
Revelation 12:9 – And the great dragon was cast out, that old serpent, called the Devil, and Satan, which deceiveth the whole world: he was cast out into the earth, and his angels were cast out with him.
Also, an adversary can be smart and be an antitype, a fitting substitute to the real one. In fact, the end times antichrist that comes onto the scene prior to the second coming of Christ, will be a man who will sit in the Temple and institute the Temple rituals.
2 Thes 2:3-4 “Let no man deceive you by any means: for that day shall not come, except there come a falling away first, and that man of sin be revealed, the son of perdition; Who opposeth and exalteth himself above all that is called God, or that is worshipped; so that he as God sitteth in the temple of God, shewing himself that he is God”
This man is described in Daniel 7:8,20,21,24,25 …”I considered the horns, and, behold, there came up among them another little horn, before whom there were three of the first horns plucked up by the roots: and, behold, in this horn were eyes like the eyes of man, and a mouth speaking great things. And of the ten horns that were in his head, and of the other which came up, and before whom three fell; even of that horn that had eyes, and a mouth that spake very great things, whose look was more stout than his fellows. I beheld, and the same horn made war with the saints, and prevailed against them. And the ten horns out of this kingdom are ten kings that shall arise: and another shall rise after them; and he shall be diverse from the first, and he shall subdue three kings. And he shall speak great words against the most High, and shall wear out the saints of the most High, and think to change times and laws: and they shall be given into his hand until a time and times and the dividing of time.”
These ten horns are ten kings and represent the ten toes of the image of Nebuchadnezzar described in Daniel 2. At the time of these ten horns/toes, a little horn will appear and “pluck out” 3 of the 10, leaving 7 horns, and this is the 8th and was the 7th beast.
From the preceding, it appears that it does not matter whether the “man of sin”, the “end-time beast” is a Muslim or not. Rather, whether the man fits all the descriptions.